High spectral and spatial resolution MRI of prostate cancer: a pilot study
| Autor: | Aritrick Chatterjee, Carla Harmath, Aytekin Oto, Milica Medved, Ajit Devaraj, Tatjana Antic, Grace M. Lee, Gregory S. Karczmar, Ambereen Yousuf |
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| Rok vydání: | 2021 |
| Předmět: |
Physics
Male Reproducibility Hiss Logarithm Receiver operating characteristic Breast imaging Prostatic Neoplasms Reproducibility of Results Pilot Projects Magnetic Resonance Imaging Article 030218 nuclear medicine & medical imaging Correlation 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance Distortion Humans Radiology Nuclear Medicine and imaging Image resolution 030217 neurology & neurosurgery |
| Zdroj: | Magn Reson Med |
| ISSN: | 1522-2594 |
| Popis: | Purpose High spectral and spatial resolution (HiSS) MRI is a spectroscopic imaging method focusing on water and fat resonances that has good diagnostic utility in breast imaging. The purpose of this work was to assess the feasibility and potential utility of HiSS MRI for the diagnosis of prostate cancer. Methods HiSS MRI was acquired at 3 T from six patients who underwent prostatectomy, yielding a train of 127 phase-coherent gradient echo (GRE) images. In the temporal domain, changes in voxel intensity were analyzed and linear (R) and quadratic (R1, R2) quantifiers of signal logarithm decay were calculated. In the spectral domain, three signal scaling-independent parameters were calculated: water resonance peak width (PW), relative peak asymmetry (PRA), and relative peak distortion from ideal Lorentzian shape (PRD). Seven cancer and five normal tissue regions of interest were identified in correlation with pathology and compared. Results HiSS-derived quantifiers, except R2, showed high reproducibility (coefficients of variation, 5%-14%). Spectral domain quantifiers performed better than temporal domain quantifiers, with receiver operator characteristic areas under the curve ranging from of 0.83 to 0.91. For temporal domain parameters, the range was 0.74 to 0.91. Low absolute values of the coefficients of correlation between monoexponential decay markers (R, PW) and resonance shape markers (PRA, PRD) were observed (range, 0.23-0.38). Conclusion The feasibility and potential diagnostic utility of HiSS MRI in the prostate at 3 T without an endorectal coil was confirmed. Weak correlation between well-performing markers indicates that complementary information could be leveraged to further improve diagnostic accuracy. |
| Databáze: | OpenAIRE |
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