CD4+/CD56+ haematodermic neoplasm: a preculsor haematological neoplasm that frequently first presents in the skin
| Autor: | JM Martín, A Ferrández-Izquierdo, Esperanza Jordá, Miguel Nicolau, A Galán, AM Ferrer |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Skin Neoplasms Dermatology Disease Immunophenotyping hemic and lymphatic diseases Medicine Neoplasm Humans Disseminated disease Purpura Aged Skin business.industry hemic and immune systems Blastic NK cell lymphoma medicine.disease CD56 Antigen stomatognathic diseases Infectious Diseases medicine.anatomical_structure Hematologic Neoplasms Natural killer cell lymphoma CD4 Antigens Bone marrow business Skin lesion |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology : JEADV. 20(9) |
| ISSN: | 0926-9959 |
| Popis: | CD4+/CD56+ hematodermic neoplasm, formerly known as blastic NK cell lymphoma, is an aggressive and rare preculsor hematologic neoplasm recently recognized by the WHO-EORTC classification consensus for cutaneous lymphomas. The neoplasm tends to affect elderly patients, who usually present with skin lesions but often have a disseminated disease, including bone marrow involvement. Although the lesions are composed of cells with a lymphoblast-like morphology and an NK-cell phenotype, exhibiting a CD4+, CD56+ positive immunophenotype, recent studies support a relationship to plasmacytoid dendritic cells. Because of the rarity of this disease, we describe two patients suffering a CD4+/CD56+ hematodermic neoplasm. |
| Databáze: | OpenAIRE |
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