Association between frailty syndrome and survival in patients with pancreatic adenocarcinoma

Autor: Nathan H. Parker, Maria Q.B. Petzel, An Ngo-Huang, Holly M. Holmes, Jude K.A. des Bordes, Juhee Song, Eduardo Bruera, David R. Fogelman, Matthew H.G. Katz
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
0301 basic medicine
Cancer Research
medicine.medical_specialty
Weakness
geriatric assessment
Frailty syndrome
Comorbidity
Kaplan-Meier Estimate
frailty
Adenocarcinoma
lcsh:RC254-282
03 medical and health sciences
Grip strength
0302 clinical medicine
Weight loss
Internal medicine
pancreatic adenocarcinoma
Humans
Medicine
Radiology
Nuclear Medicine and imaging
Stage (cooking)
cancer survival
Aged
Neoplasm Staging
Original Research
Aged
80 and over
Performance status
business.industry
Clinical Cancer Research
Middle Aged
Prognosis
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
3. Good health
Pancreatic Neoplasms
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Cohort
Body Composition
Female
geriatric syndromes
medicine.symptom
business
Zdroj: Cancer Medicine, Vol 8, Iss 6, Pp 2867-2876 (2019)
Cancer Medicine
ISSN: 2045-7634
Popis: Background Frailty is a syndrome characterized by weakness, slow gait, weight loss, exhaustion, and low activity. We sought to determine whether frailty was associated with age or stage in newly diagnosed patients with pancreatic ductal adenocarcinoma (PDAC), and determine its association with survival. Methods Consecutive patients with newly diagnosed PDAC of all stages underwent baseline assessment. Frailty (per Fried criteria) was defined as having three or more abnormalities in: grip strength, gait speed, weight loss, self‐reported exhaustion, or self‐reported physical activity. Baseline clinicodemographic characteristics, anatomic stage, performance status, and laboratory markers of prognosis were included. The association between baseline characteristics, frailty, and survival was determined. The associations of individual frailty measures with age, stage, comorbidities, and performance status were examined. Body composition was measured from computed tomographic images using SliceOMatic software. Results Of 150 patients enrolled, 8 were excluded because they did not have PDAC on final diagnosis. The median age was 65 years (range, 32‐89). Seventy‐nine patients (55.6%) were sarcopenic, and 36 (25.4%) were frail. Frailty was associated with increasing comorbidities (P = 0.03) and worse performance status (P
Databáze: OpenAIRE
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