Evidence for an immune function of lepidopteran silk proteins
| Autor: | Christine Lesch, Thomas Hauling, Marco Fabbri, Mitchell S. Dushay, Ulrich Theopold, Ahmed M. Korayem, Olga Loseva, Otto Schmidt, Malin Lindgren |
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| Rok vydání: | 2007 |
| Předmět: |
animal structures
Silk Biophysics macromolecular substances Biology Biochemistry Immune system Immunity Hemolymph Animals Tissue Distribution Blood Coagulation Molecular Biology Clotting factor Wound Healing Hemolymph coagulation Evidence-Based Medicine Innate immune system fungi Ephestia Cell Biology biochemical phenomena metabolism and nutrition biology.organism_classification Cell biology Lepidoptera Galleria mellonella SILK Organ Specificity Immunology Fibroins |
| Zdroj: | Biochemical and Biophysical Research Communications. 352:317-322 |
| ISSN: | 0006-291X |
| Popis: | Hemolymph coagulation stops bleeding and protects against infection. Clotting factors include both proteins that are conserved during evolution as well as more divergent proteins in different species. Here we show that several silk proteins also appear in the clot of the greater wax moth Galleria mellonella. RT-PCR analysis reveals that silk proteins are expressed in immune tissues and induced upon wounding in both Galleria and Ephestia kuehniella, a second pyralid moth. Our results support the idea that silk proteins were co-opted for immunity and coagulation during evolution. |
| Databáze: | OpenAIRE |
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