Human intrathymic development: a selective approach
| Autor: | Tessa Kerre, Georges Leclercq, Tom Taghon, Bart Vandekerckhove, Jean Plum, M De Smedt |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Stromal cell
T-Lymphocytes Immunology Receptors Antigen T-Cell Notch signaling pathway CD34 Cell Differentiation Thymus Gland Biology Hematopoietic Stem Cells Cell biology Mice Thymic Tissue Antigen Antigens CD T-Lymphocyte Subsets Animals Humans Immunology and Allergy Cytotoxic T cell Progenitor cell Immunodeficient Mouse |
| Zdroj: | Seminars in Immunopathology. 30:411-423 |
| ISSN: | 1863-2300 1863-2297 |
| DOI: | 10.1007/s00281-008-0135-2 |
| Popis: | Human T lymphocytes can be generated from CD34 progenitor cells from different sources. This can be obtained in an in vivo model wherein human thymic tissue and fetal liver is transplanted in an immunodeficient mouse. However, human T cells are also generated in immunodeficient mice without co-transplantation of human thymus or in in vitro hybrid human-mouse fetal thymus organ culture. This shows that xenogeneic mouse thymus tissue supports human T cell differentiation. Finally, human T cells are generated on co-culture with murine stromal cells that express the Delta-like1 ligand for the Notch receptor. How these different environments influence the human T cell repertoire is reviewed and discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|