Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Turkey: 2008-2014

Autor: Arzu Karli, Candan Öztürk, Hakan Uslu, Efgan Dogan Gayyurhan, Abdurrahman Kiremitci, Akgün Yaman, Cüneyt Özakin, Eda Karadag Oncel, Hatice Ozcinar, Hüseyin Güdücüoğlu, Zeynep Gülay, Nezahat Gürler, Mustafa Gül, Nezahat Akpolat, Duygu Perçin, Faruk Aydin, Melda Celik, Melike Emiroglu, Mehmet Ceyhan, Meral Gültekin, Yildiz Camcioglu, Serife Yuksekkaya, Keramettin Yanik, Lütfiye Öksüz, Yasemin Zer, Sengul Ozkan, Laser Şanal, Yasemin Ozsurekci, Şöhret Aydemir, Gülçin Bayramoğlu
Přispěvatelé: Selçuk Üniversitesi, OMÜ, Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı., Özakın, Cüneyt, AAG-8392-2021, Çocuk Sağlığı ve Hastalıkları, Çukurova Üniversitesi, Ege Üniversitesi
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Serotype
Preventive health service
Male
10-valent pneumococcal conjugate vaccine
Heptavalent Pneumococcal Conjugate Vaccine
Turkey
Pneumococcal Vaccines
Streptococcus Pneumoniae
Haemophilus Influenzae GlpQ Protein
Bacterial meningitis
Early impact
Bacteremia
medicine.disease_cause
Pneumococcal conjugate vaccine
Turkey (republic)
0302 clinical medicine
Sequential introduction
Prevalence
Immunology and Allergy
030212 general & internal medicine
Prospective Studies
Child
Antiinfective agent
Biotechnology & applied microbiology
Immunization plan
Minimum inhibitory concentration
Vaccination
Microbial sensitivity test
Classification
Research Papers
Multicenter study
Hospitals
Era
Anti-Bacterial Agents
Clinical trial
Pneumococcal infections
ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS
Streptococcus pneumoniae
Child
Preschool
surveillance
Female
epidemiology
Bacterium isolation
InformationSystems_MISCELLANEOUS
Clinical decision making
Pneumococcal infection
medicine.drug
Human
Turkish population
030106 microbiology
Immunology
Microbial Sensitivity Tests
Serogroup
Microbiology
Article
Pneumococcal Infections
03 medical and health sciences
Hospital
Sepsis
medicine
Humans
Prospective study
Empyema
Pharmacology
Drug effects
Vaccines
Conjugate
business.industry
Immunization Programs
ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS
medicine.disease
Nonhuman
Virology
13-valent pneumococcal vaccine
S. pneumoniae
Penicillin
Pneumococcus vaccine
ComputingMethodologies_PATTERNRECOGNITION
serotypes
Preschool child
Isolation and purification
business
Popis: WOS: 000371745700019
PubMed ID: 26325175
Successful vaccination policies for protection from invasive pneumococcal diseases (IPD) dependent on determination of the exact serotype distribution in each country. We aimed to identify serotypes of pneumococcal strains causing IPD in children in Turkey and emphasize the change in the serotypes before and after vaccination with 7-valent pneumococcal conjugate vaccine (PCV-7) was included and PCV-13 was newly changed in Turkish National Immunization Program. Streptococcus pneumoniae strains were isolated at 22 different hospitals of Turkey, which provide healthcare services to approximately 65% of the Turkish population. Of the 335 diagnosed cases with S. pneumoniae over the whole period of 2008-2014, the most common vaccine serotypes were 19F (15.8%), 6B (5.9%), 14 (5.9%), and 3 (5.9%). During the first 5y of age, which is the target population for vaccination, the potential serotype coverage ranged from 57.5 % to 36.8%, from 65.0% to 44.7%, and from 77.4% to 60.5% for PCV-7, PCV-10, and PCV-13 in 2008-2014, respectively. The ratio of non-vaccine serotypes was 27.2% in 2008-2010 whereas was 37.6% in 2011-2014 (p=0.045). S. penumoniae serotypes was less non-susceptible to penicillin as compared to our previous results (33.7vs 16.5 %, p=0.001). The reduction of those serotype coverage in years may be attributed to increasing vaccinated children in Turkey and the increasing non-vaccine serotype may be explained by serotype replacement. Our ongoing IPD surveillance is a significant source of information for the decision-making processes on pneumococcal vaccination.
PfizerPfizer
This study was supported by Pfizer.
Databáze: OpenAIRE
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