High-sensitivity C-reactive protein (hs-CRP) level in children with nephrotic syndrome
| Autor: | Jolanta Tobolczyk, Walentyna Zoch-Zwierz, Anna Wasilewska, Edyta Tenderenda |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Nephrology medicine.medical_specialty Nephrotic Syndrome Adolescent Group ii Gastroenterology Recurrence Prednisone Internal medicine medicine Humans Child Glucocorticoids Proteinuria biology business.industry C-reactive protein Serum concentration medicine.disease C-Reactive Protein Endocrinology Child Preschool Pediatrics Perinatology and Child Health Cyclosporine biology.protein Female medicine.symptom business Nephrotic syndrome Immunosuppressive Agents Glucocorticoid medicine.drug |
| Zdroj: | Pediatric Nephrology. 22:403-408 |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/s00467-006-0336-7 |
| Popis: | The aim of this study was to assess the serum concentration of high-sensitivity C-reactive protein (hs-CRP) in children with nephrotic syndrome (NS) treated with prednisone and cyclosporine A (CyA). Patients were divided into three groups: (I) 20 NS children (aged 4–14 years) in relapse and examined twice, (A) before treatment and (B) after proteinuria regression (a 3–4 week course of prednisone therapy); (II) 20 children with steroid-dependent or steroid-resistant NS, treated with CyA, also examined twice, (D) before treatment with CyA, (E) 6 months after therapy. A control group (C) consisted of 20 healthy children. Serum hs-CRP level was determined by a nephelometric method with a Behring Nephelometer 100 Analyzer, Dade Behring. The results showed that median hs-CRP concentration was the highest in children with relapsing steroid-sensitive NS before treatment (IA). After proteinuria regression (IB), the hs-CRP level had decreased and did not differ from that of healthy controls (C) (P > 0.05). In group II, before CyA administration (IID), the level of hs-CRP was normal, but it had increased after 6 months of treatment (IIE) up to a level six-times higher than that of the control group (P < 0.01). We concluded that, in children with steroid-sensitive nephrotic syndrome in relapse, the serum hs-CRP level is increased but returns to normal after 3–4 weeks of glucocorticoid treatment. In children chronically treated with CyA due to NS, serum hs-CRP level increases significantly during the therapy. |
| Databáze: | OpenAIRE |
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