Reaction of Diazo Compounds with Difluorocarbene: An Efficient Approach towards 1,1-Difluoroolefins
| Autor: | Yan Zhang, Chengpeng Wang, Chenggui Wu, Weizhi Yu, Jianbo Wang, Zhikun Zhang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Difluorocarbene 010405 organic chemistry Carbene dimerization Hydrazone chemistry.chemical_element General Medicine General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis Relative stability 0104 chemical sciences chemistry.chemical_compound chemistry Tetrabutylammonium bromide Fluorine Organic chemistry Diazo Carbene |
| Zdroj: | Angewandte Chemie International Edition. 55:273-277 |
| ISSN: | 1433-7851 |
| DOI: | 10.1002/anie.201509711 |
| Popis: | A transition-metal-free difluoromethylenation of diazo compounds that proceeds under mild conditions has been developed and is based on the use of TMSCF2 Br as the difluoromethylene source and tetrabutylammonium bromide (TBAB) as the promoter. The chemoselective formal carbene dimerization reaction is achieved owing to the electronic properties and the relative stability of the difluorocarbene intermediate. |
| Databáze: | OpenAIRE |
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