Invasive pneumococcal disease in patients with haematological malignancies before routine use of conjugate vaccines in Finland
| Autor: | Peter Klemets, Outi Lyytikäinen, Janne Aittoniemi, J. Pekka Nuorti, Vesa Lindström, Jukka Ollgren, Marjatta Sinisalo, Raija Silvennoinen |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Serotype Adult Male medicine.medical_specialty Adolescent 030106 microbiology Population Pneumococcal Infections Herd immunity Cohort Studies Pneumococcal Vaccines 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine medicine Humans In patient 030212 general & internal medicine Young adult education Child Finland Aged Aged 80 and over education.field_of_study Vaccines Conjugate General Immunology and Microbiology business.industry Infant General Medicine Middle Aged medicine.disease 3. Good health Vaccination Pneumococcal infections Infectious Diseases Child Preschool Hematologic Neoplasms Immunology Female business Cohort study |
| Zdroj: | Infectious diseases (London, England). 48(5) |
| ISSN: | 2374-4243 |
| Popis: | The baseline national invasive pneumococcal disease (IPD) incidence rate, serotype distribution and serotype coverage of pneumococcal vaccines were evaluated in patients with Hodgkin's and non-Hodgkin's lymphomas, myeloma and leukaemia within 1 year after haematological diagnosis during 1995-2002, before introduction of pneumococcal conjugate vaccines. Pneumococcal serotype distribution among these patients was different from serotypes causing IPD in the general population. The serotype coverages of PCV13 and PPSV23 were 57% and 64%, respectively, lower than in the general population. This reflects a higher predisposition to IPD in vaccinated patients with haematological malignancies and possibly less benefit of herd immunity gained with the wide use of pneumococcal conjugate vaccines in the general population. This data will be useful as a baseline for determining the future role of adult PCV vaccination in these patient groups. |
| Databáze: | OpenAIRE |
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