Large granular leukemia with concurrent central nervous system and articular infiltration in a cat☆

Autor: Sara Belluco, Luc Chabanne, David Sayag, Frédérique Ponce, Benoit Rannou, E. Segard, T. Bouzouraa, J. L. Cadoré
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Pathology
medicine.medical_specialty
040301 veterinary sciences
FIV
Feline Immunodeficiency Virus
Population
COP
Cyclophosphamide
Oncovin
Prednisolone
RBC
Red Blood Cells
CBC
Complete Blood Count
Article
0403 veterinary science
SAA
Serum Amyloid A
03 medical and health sciences
Lethargy
NK
Natural Killer
0302 clinical medicine
FNA
Fine Needle Aspirates
Medicine
Mesenteric lymph nodes
Synovial fluid
PCR
Polymerase Chain Reaction
Small Animals
education
Large granular lymphocyte
Leukemia
CNS
Articular infiltration
Cat
FA
Felty's Syndrome
education.field_of_study
medicine.diagnostic_test
business.industry
04 agricultural and veterinary sciences
medicine.disease
CNS
Central Nervous System
RA
Rheumatoid Factors
Leukemia
medicine.anatomical_structure
WBC
White Blood Cells
030220 oncology & carcinogenesis
Abdominal ultrasonography
LGL
Large Granula Lymphocytes
Prednisolone
Bone marrow
business
LN
Lymph Node
CSF
Cerebrospinal Fluid
medicine.drug
FeLV
Feline Leukemia Virus
Zdroj: Revue Vétérinaire Clinique
ISSN: 2214-5680
2214-5672
Popis: Summary A 2-year-old female domestic shorthair cat was referred with a 2 month history of lethargy, weight loss, recurrent hyperthermia and polyarthropathy despite prednisolone. Upon physical examination, the cat showed apathy, hyperthermia, multiple appendicular joint pain and swelling. The CBC showed severe macrocytic normochromic non-regenerative anemia and thrombocytopenia. A population of immature large granular lymphocytes (LGL) was noted on blood smear. Abdominal ultrasonography revealed enlarged mesenteric lymph nodes (LNs), hyper echoic liver and splenomegaly. Cytology of fine needle aspirate of synovial fluid, spleen, liver, enlarged abdominal LNs and bone marrow supported a diagnosis of LGL leukemia with concurrent articular infiltration. A COP-based protocol was initiated with L-asparaginase (400 UI/kg intramuscularly) and prednisolone (1 mg/kg/day orally). However, the cat presented 1 week later with obtundation and paresis, indicating the involvement of the central nervous system (CNS). LGL were also observed on cerebrospinal fluid analysis. Histologic examination noted LGL in the spleen, liver and LNs. Immunohistochemistry (IHC) yielded negative results for both B- and T-cells thus suggesting NK-cells. The diagnosis was LGL leukemia with concurrent articular and CNS involvement. Articular infiltration with LGL is rarely reported in small animals, whereas CNS involvement was previously only suspected in a cat at necropsy.
Databáze: OpenAIRE
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