Regenerating Damaged Myocardium: A Review of Stem-Cell Therapies for Heart Failure
| Autor: | Hanrong Wu, Kaichao Pan, Huashan Peng, Rongxue Wu, Dihan Fan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty QH301-705.5 Somatic cell Induced Pluripotent Stem Cells iPSCs ESC Review biology_other Bioinformatics myocardial repair cardiovascular disease medicine Animals Humans Regeneration Myocardial infarction Biology (General) Induced pluripotent stem cell Cause of death Heart Failure Clinical Trials as Topic business.industry Myocardium Transdifferentiation Cardiac myocyte differentiation General Medicine medicine.disease Heart failure cardiovascular system Stem cell business Stem Cell Transplantation |
| Zdroj: | Cells Cells, Vol 10, Iss 3125, p 3125 (2021) |
| Popis: | Cardiovascular disease (CVD) is one of the contributing factors to more than one-third of human mortality and the leading cause of death worldwide. The death of cardiac myocyte is a fundamental pathological process in cardiac pathologies caused by various heart diseases, including myocardial infarction. Thus, strategies for replacing fibrotic tissue in the infarcted region with functional myocardium have long been a goal of cardiovascular research. This review begins by briefly discussing a variety of somatic stem- and progenitor-cell populations that were frequently studied in early investigations of regenerative myocardial therapy and then focuses primarily on pluripotent stem cells (PSCs), especially induced-pluripotent stem cells (iPSCs), which have emerged as perhaps the most promising source of cardiomyocytes for both therapeutic applications and drug testing. We also describe attempts to generate cardiomyocytes directly from cardiac fibroblasts (i.e., transdifferentiation), which, if successful, may enable the pool of endogenous cardiac fibroblasts to be used as an in-situ source of cardiomyocytes for myocardial repair. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|