Perinatal Fluoxetine Exposure Impairs the CO2 Chemoreflex. Implications for Sudden Infant Death Syndrome
| Autor: | Jaime Eugenín, Isabel Llona, Karina Bravo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors Respiratory rate Clinical Biochemistry Biology Solitary tract nucleus Hypercapnia Mice 03 medical and health sciences 0302 clinical medicine Pregnancy Fluoxetine Internal medicine Reflex medicine Animals Humans Respiratory system Molecular Biology Neurons Infant Cell Biology Carbon Dioxide Sudden infant death syndrome medicine.disease Respiratory acidosis 030104 developmental biology Endocrinology Animals Newborn Breathing Female medicine.symptom Pulmonary Ventilation Raphe nuclei Sudden Infant Death 030217 neurology & neurosurgery Brain Stem |
| Zdroj: | American Journal of Respiratory Cell and Molecular Biology. 55:368-376 |
| ISSN: | 1535-4989 1044-1549 |
| Popis: | High serotonin levels during pregnancy affect central nervous system development. Whether a commonly used antidepressant such as fluoxetine (a selective serotonin reuptake inhibitor) taken during pregnancy may adversely affect respiratory control in offspring has not been determined. The objective was to determine the effect of prenatal-perinatal fluoxetine exposure on the respiratory neural network in offspring, particularly on central chemoreception. Osmotic minipumps implanted into CF-1 mice on Days 5-7 of pregnancy delivered 7 milligrams per kilogram per day of fluoxetine, achieving plasma levels within the range found in patients. Ventilation was assessed in offspring at postnatal Days 0-40 using head-out body plethysmography. Neuronal activation was evaluated in the raphe nuclei and in the nucleus tractus solitarius by c-Fos immunohistochemistry during normoxic eucapnia and hypercapnia (10% CO2). Respiratory responses to acidosis were evaluated in brainstem slices. Prenatal-perinatal fluoxetine did not affect litter size, birth weight, or the postnatal growth curve. Ventilation under eucapnic normoxic conditions was similar to that of control offspring. Fluoxetine exposure reduced ventilatory responses to hypercapnia at P8-P40 (P |
| Databáze: | OpenAIRE |
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