Host Transcription Profile in Nasal Epithelium and Whole Blood of Hospitalized Children Under 2 Years of Age With Respiratory Syncytial Virus Infection

Autor: Ngoc Quang Minh Ngo, Juliet E. Bryant, Jeremy Farrar, Hong Nhien Trinh, H. Rogier van Doorn, Bertrand De Meulder, Menno de Jong, Quang Tung Thai, Bao Tinh Le Binh, Quoc Bao Vo, Anh Tuan Tran, Lien Anh Ha Do, Thu Van Tran, Thanh Vu Vo, Johann Pellet, Thi Thu Loan Tran, Thi Dang, Jorrit-Jan H. Hofstra, Martin L. Hibberd, Quynh Huong Tran, Ngoc Huong Cao, Nguyen Anh Tran Dac, Charles Auffray, Thi Thanh Hai Nguyen, Huu Mai Khanh Nguyen, Bach Hue Nguyen, Lu Viet Ho, Minh Tien Nguyen
Přispěvatelé: Medical Microbiology and Infection Prevention, AII - Amsterdam institute for Infection and Immunity, AII - Infectious diseases
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Pathogenesis and Host Response
0301 basic medicine
Chemokine
respiratory syncytial virus
Common Cold
Respiratory Mucosa
Respiratory Syncytial Virus Infections
medicine.disease_cause
host expression profile
Virus
Cohort Studies
Major Articles and Brief Reports
03 medical and health sciences
Immune system
immune system diseases
Interferon
hemic and lymphatic diseases
medicine
Humans
Immunology and Allergy
Respiratory Tract Infections
Blood Cells
Innate immune system
biology
Respiratory tract infections
business.industry
Gene Expression Profiling
children under 2 years old
Infant
Newborn
virus diseases
Infant
Common cold
medicine.disease
Immunity
Innate
Respiratory Syncytial Viruses
3. Good health
Hospitalization
rhinovirus
030104 developmental biology
Infectious Diseases
lower respiratory tract infections
Child
Preschool
Immunology
biology.protein
Female
Rhinovirus
business
medicine.drug
Zdroj: Journal of infectious diseases, 217(1), 134-146. Oxford University Press
The Journal of Infectious Diseases
ISSN: 0022-1899
Popis: RSV infection induces a clearly different host response pattern compared with hRV and induced strong innate immune responses both locally and systemically. B cell lymphoma (BCL6) is a hub gene that positively correlates with RSV load and disease severity.
Background Most insights into the cascade of immune events after acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. Methods In this study, we investigated host gene expression profiles in nasopharyngeal (NP) swabs and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalized patients
Databáze: OpenAIRE
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