Up-regulation of circulating adhesionmolecules in bronchiectasis
| Autor: | Wing Lam, IH Shum, L. Zheng, Kwt Tsang, George L. Tipoe, Mary S.M. Ip, R.Y.H Leung, James Chung-Man Ho, G. C. Ooi |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Vital Capacity Intercellular Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Enzyme-Linked Immunosorbent Assay Statistics Nonparametric FEV1/FVC ratio Forced Expiratory Volume Internal medicine E-selectin medicine Humans Aged Bronchiectasis Lung biology business.industry Cell adhesion molecule Sputum Adhesion Middle Aged medicine.disease Intercellular adhesion molecule Up-Regulation Endocrinology medicine.anatomical_structure Case-Control Studies Immunology biology.protein Female E-Selectin business |
| Zdroj: | European Respiratory Journal. 16:691 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1034/j.1399-3003.2000.16d21.x |
| Popis: | Adhesion molecules are expressed on the surface of endothelial cells and leukocytes and are responsible for mediating the migration of intravascular leukocytes into inflamed tissue. Intensive recruitment of neutrophils into the airways occurs in bronchiectasis, although little is known about the role of adhesion molecules in this process. The authors, therefore, determined serum levels of E-selectin, intercellular adhesion molecule (ICAM)-1 and vascular adhesion molecule (VCAM)-1 in stable bronchiectasis patients (n=37) and healthy control subjects (n=17), and evaluated their relationship with clinical markers of disease severity in bronchiectasis. Serum levels of E-selectin, ICAM-1 and VCAM-1 in bronchiectasis patients were significantly higher than those in control subjects (p=0.02 |
| Databáze: | OpenAIRE |
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