Tests of emotional behavior in rats following depletion of norepinephrine, of serotonin, or of both
| Autor: | David E. Bresler, Gaylord Ellison |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Serotonin Sucrose medicine.medical_specialty Light Drinking Behavior Open field Norepinephrine (medication) Hydroxydopamines Norepinephrine Behavioral syndrome Internal medicine medicine Animals Humans Pharmacology Behavior Animal Quinine Aggression Fenclonine Reserpine Rats Endocrinology Anesthesia Shock (circulatory) Emotional behavior medicine.symptom Psychology Locomotion medicine.drug |
| Zdroj: | Psychopharmacologia. 34:275-288 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf00422552 |
| Popis: | Groups of rats were depleted of norepinephrine (using 6-OHDA), of serotonin (using chronic PCPA), or of both, and were tested on a variety of behavioral tasks. 6-OHDA treated rats and PCPA treated rats showed different and in many cases opposed behavioral syndromes, but animals which received both drugs generally showed the greatest behavioral disruptions. Animals receiving PCPA showed decreased locomotion (freezing) in quiet novel environments but increased locomotion when stimulated, as well as increased shock elicited aggression. Rats receiving 6-OHDA showed an initially decreased rate of rearing in open field and decreased sucrose consumption when food deprived. The results are discussed in terms of the reserpine model of depression. |
| Databáze: | OpenAIRE |
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