Confirmation that heparin is an alternative means of promoting early reperfusion
| Autor: | Latado Al, Esteves Fp, Rabelo Júnior A, Azevedo Júnior A, Silva Pr, Esteves Jp, Souza Vp, José Carlos Brito, Braga J, Rocha Ms, Teixeira Ms, Godinho Ag |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Blood transfusion medicine.medical_treatment Myocardial Infarction Myocardial Reperfusion Placebo Bolus (medicine) Double-Blind Method Fibrinolytic Agents Humans Medicine Myocardial infarction Angioplasty Balloon Coronary Aged Aspirin Heparin business.industry General Medicine Thrombolysis Middle Aged medicine.disease Combined Modality Therapy Surgery Anesthesia Drug Therapy Combination Female Cardiology and Cardiovascular Medicine business Fibrinolytic agent medicine.drug |
| Zdroj: | Coronary Artery Disease. 9:335-338 |
| ISSN: | 0954-6928 |
| Popis: | BACKGROUND: New strategies to increase coronary patency rate before primary angioplasty are under discussion. We tested the hypothesis that use of a high dose of a standard heparin bolus could achieve an acceptable rate of re-opening occluded infarct-related arteries thus providing an alternative to chemical thrombolysis before admission of the patient to hospital, and a pretreatment for primary angioplasty. METHODS: Forty-eight patients who presented within 12 h of acute myocardial infarction with ST segment elevation were assigned randomly to groups to receive aspirin (200 mg orally) and high-dose standard heparin 300 U/kg as an intravenous bolus (n = 25), or aspirin and placebo bolus (n = 23). Thereafter, all patients underwent coronary arteriography to assess their suitability for primary angioplasty. RESULTS: The high-dose heparin group had greater patency rate (Thrombolysis in Myocardial Infarction grade 2 or 3 flow in the infarct-related artery) than the placebo group (52% compared with 13%, P = 0.006). Hemorrhages related to the puncture site that required blood transfusion occurred in two of 25 and in one of 23 patients in the high-dose heparin and placebo groups, respectively. CONCLUSION: Our study suggests that high-dose standard heparin does have a thrombolytic action when administered as an intravenous bolus. |
| Databáze: | OpenAIRE |
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