Clinical and microbiologic efficacy and safety profile of linezolid, a new oxazolidinone antibiotic
| Autor: | Giampaolo Corti, Roberta Cinelli, Franco Paradisi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Micrococcaceae medicine.drug_class Antibiotics Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology chemistry.chemical_compound Antibiotic resistance Internal medicine Acetamides medicine Humans Pharmacology (medical) Gram-positive cocci antibiotic resistance enterococci staphylococci pneumococci linezolid Gram-Positive Cocci Gram-Positive Bacterial Infections Oxazolidinones Antibacterial agent Clinical Trials as Topic Linezolid Streptococcus General Medicine bacterial infections and mycoses biology.organism_classification Drug Resistance Multiple Anti-Bacterial Agents Community-Acquired Infections Infectious Diseases Treatment Outcome chemistry Enterococcus Staphylococcus aureus bacteria |
| Zdroj: | International journal of antimicrobial agents. 16(4) |
| ISSN: | 0924-8579 |
| Popis: | Gram-positive cocci are important causes of infection both in the community and in the hospital, with repercussions on mortality and increased economic costs. Treatment of these infections is made difficult by the increasing emergence of multi-resistant organisms, primarily among Gram-positive cocci, such as vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci, and penicillin-resistant pneumococci. Linezolid, a member of the new class of synthetic antimicrobials named oxazolidinones, has several favourable characteristics including high activity against multiresistant Gram-positive cocci. In a number of clinical trials, linezolid showed good clinical and microbiologic efficacy in the therapy of infections caused by these organisms. It can be considered a valid option for treating both community- and hospital-acquired infections due to multiresistant Gram-positive cocci. |
| Databáze: | OpenAIRE |
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