Characterization of Nkx6-2-derived neocortical interneuron lineages
| Autor: | Gord Fishell, Jens Hjerling-Leffler, Theofanis Karayannis, Goichi Miyoshi, Vitor H. Sousa |
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| Přispěvatelé: | University of Zurich, Fishell, Gord |
| Rok vydání: | 2009 |
| Předmět: |
2805 Cognitive Neuroscience
Lineage (genetic) animal structures Interneuron Ganglionic eminence Cognitive Neuroscience 2804 Cellular and Molecular Neuroscience 610 Medicine & health Neocortex Biology 03 medical and health sciences Cellular and Molecular Neuroscience Mice 0302 clinical medicine Fate mapping Interneurons medicine Animals Tissue Distribution Transcription factor Loss function 030304 developmental biology Homeodomain Proteins Mice Knockout genetic fate mapping 0303 health sciences 10242 Brain Research Institute interganglionic sulcus Articles whole-cell physiology mouse genetics medicine.anatomical_structure nervous system loss of function embryonic structures Homeobox 570 Life sciences biology Calretinin Neuroscience 030217 neurology & neurosurgery Transcription Factors |
| Zdroj: | Cerebral Cortex (New York, NY) |
| ISSN: | 1460-2199 |
| Popis: | Ventral telencephalic progenitors expressing the homeodomain transcription factor Nkx6-2 have been shown to give rise to a multitude of cortical interneuron subtypes usually associated with origin in either the medial ganglionic eminence or the caudal ganglionic eminence. The function of Nkx6-2 in directing the fate of those progenitors has, however, not been thoroughly analyzed. We used a combination of genetic inducible fate mapping and in vivo loss-of-function to analyze the requirement of Nkx6-2 in determining the fate of cortical interneurons. We have found that interneuron subtypes are born with a characteristic temporal pattern. Furthermore, we extend the characterization of interneurons from the Nkx6-2 lineage through the application of electrophysiological methods. Analysis of these populations in Nkx6-2 null mice suggests that there is a small and partially penetrant loss of delayed non-fast spiking somatostatin/calretinin double positive cortical interneurons in the absence of Nkx6-2 gene function. |
| Databáze: | OpenAIRE |
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