Sensitivity of peripheral blood lymphocytes from breast cancer patients to glucocorticoids
| Autor: | I. A. Ioannesyants, E. B. Polevaya |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty Drug Resistance Stimulation Breast Neoplasms Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Breast cancer Internal medicine RNA polymerase medicine Humans Lymphocytes Phytohemagglutinins Glucocorticoids Dexamethasone Binding Sites General Medicine DNA-Directed RNA Polymerases medicine.disease Peripheral blood Endocrinology chemistry Female Glucocorticoid Intracellular medicine.drug Hormone |
| Zdroj: | Bulletin of experimental biology and medicine. 141(1) |
| ISSN: | 0007-4888 |
| Popis: | We measured DNA-dependent RNA polymerase activity, calculated hormone-binding sites and intracellular association constant under conditions of phytohemagglutinin stimulation and dexamethasone treatment, and studied the interaction of cells with the glucocorticoid covalently bound to an inert carrier not penetrating into cells. Reduced sensitivity of peripheral blood lymphocytes from breast cancer patients to glucocorticoids was demonstrated. The biological mechanisms for hormonal regulation are reviewed here. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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