Species-specific differences in synaptic transmission and plasticity
Autor: | Prateep Beed, Saikat Ray, Laura Moreno Velasquez, Alexander Stumpf, Daniel Parthier, Aarti Swaminathan, Noam Nitzan, Jörg Breustedt, Liora Las, Michael Brecht, Dietmar Schmitz |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
genetics [Synaptic Transmission]
anatomy & histology [Hippocampus] physiology [Hippocampus] lcsh:Medicine Gene Expression physiology [Neural Pathways] genetics [Neuronal Plasticity] Hippocampus Synaptic Transmission metabolism [Synaptotagmins] Article Synaptic plasticity Mice Synaptotagmins Species Specificity Memory physiology [Synaptotagmins] Chiroptera Neural Pathways physiology [Neuronal Plasticity] Animals Learning physiology [Learning] lcsh:Science physiology [Memory] Neuronal Plasticity Shrews lcsh:R nervous system physiology [Synaptic Transmission] genetics [Synaptotagmins] lcsh:Q Function and Dysfunction of the Nervous System ddc:600 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit |
Zdroj: | Scientific Reports Scientific reports 10(1), 16557 (2020). doi:10.1038/s41598-020-73547-6 Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) |
Popis: | Synaptic transmission and plasticity in the hippocampus are integral factors in learning and memory. While there has been intense investigation of these critical mechanisms in the brain of rodents, we lack a broader understanding of the generality of these processes across species. We investigated one of the smallest animals with conserved hippocampal macroanatomy—the Etruscan shrew, and found that while synaptic properties and plasticity in CA1 Schaffer collateral synapses were similar to mice, CA3 mossy fiber synapses showed striking differences in synaptic plasticity between shrews and mice. Shrew mossy fibers have lower long term plasticity compared to mice. Short term plasticity and the expression of a key protein involved in it, synaptotagmin 7 were also markedly lower at the mossy fibers in shrews than in mice. We also observed similar lower expression of synaptotagmin 7 in the mossy fibers of bats that are evolutionarily closer to shrews than mice. Species specific differences in synaptic plasticity and the key molecules regulating it, highlight the evolutionary divergence of neuronal circuit functions. |
Databáze: | OpenAIRE |
Externí odkaz: |