Synthesis of novel heteroleptic delocalised cationic pyrazole gold complexes as potent HepG2 cytotoxic agents
| Autor: | Eddy M. E. Viseux, Fatai Afolabi, Clement Lemaitre, Neil Crickmore, Guillaume Riviere, Wided Souissi, Mark Roe |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cell Survival
Antineoplastic Agents Chemistry Techniques Synthetic Pyrazole 010402 general chemistry 01 natural sciences Inorganic Chemistry RC0254 chemistry.chemical_compound Perchlorate Cytotoxic T cell Humans QD Viability assay Cytotoxicity RM0300 RS0420 010405 organic chemistry Chemistry QD0411 Cationic polymerization Regioselectivity Hep G2 Cells Combinatorial chemistry 0104 chemical sciences Cell culture Drug Design Pyrazoles Gold QD0146 RC0261 Organogold Compounds QD0241 |
| Zdroj: | Dalton transactions (Cambridge, England : 2003). 47(43) |
| ISSN: | 1477-9234 1477-9226 |
| Popis: | A new series of cationic gold(I) pyrazole complexes were prepared in excellent yields as their perchlorate salts. Results of cell viability assays show that these novel complexes have good cytotoxic properties against the human HepG2 cancer cell line. These complexes showed promising anti-cancer activities and to our knowledge, pyrazoles have never been tested against this cell line. The regioselectivity of the complexation is also discussed in regards to the substitution pattern of the pyrazoles. |
| Databáze: | OpenAIRE |
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