An increase of C-reactive protein is associated with enhanced activation of endogenous fibrinolysis at baseline but an impaired endothelial fibrinolytic response after venous occlusion
| Autor: | Johann Wojta, Kurt Huber, Alexander Geppert, Andrea Zeiner, Gerald Maurer, Alexander Niessner, Mariam Nikfardjam, Gerlinde Zorn, Nelli Jordanova, Wolfgang Schreiber, Walter S. Speidl |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Endothelium medicine.medical_treatment Myocardial Infarction Inflammation Coronary Artery Disease Basal (phylogenetics) Internal medicine Plasminogen Activator Inhibitor 1 Fibrinolysis medicine Humans Thrombus Aged biology business.industry C-reactive protein Middle Aged medicine.disease C-Reactive Protein Endocrinology medicine.anatomical_structure Tissue Plasminogen Activator Multivariate Analysis Immunology biology.protein Female Tumor necrosis factor alpha Endothelium Vascular medicine.symptom Cardiology and Cardiovascular Medicine business Plasminogen activator |
| Zdroj: | Journal of the American College of Cardiology. 45:30-34 |
| ISSN: | 0735-1097 |
| Popis: | ObjectivesThe goal of this study was to determine whether chronic inflammation of the vascular wall may be associated with an impaired activation of the fibrinolytic system.BackgroundInflammation plays an important role in the initiation and progression of atherosclerosis, and the fibrinolytic system may prevent local thrombus formation.MethodsWe included 50 patients six months after their first myocardial infarction. Plasma levels of the inflammatory marker C-reactive protein (CRP) were determined at basal conditions, and the fibrinolytic parameters tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type-1 (PAI-1) were measured at basal conditions and after a standardized venous occlusion (VO) of the forearm.ResultsPatients with high CRP levels (≥3 mg/l) showed a significantly higher t-PA activity at baseline compared with patients with medium (1 to 2.9 mg/l) and low ( |
| Databáze: | OpenAIRE |
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