Coronary Flow Assessment Using 3-Dimensional Ultrafast Ultrasound Localization Microscopy
| Autor: | Oscar Demeulenaere, Zulma Sandoval, Philippe Mateo, Alexandre Dizeux, Olivier Villemain, Romain Gallet, Bijan Ghaleh, Thomas Deffieux, Charlie Deméné, Mickael Tanter, Clément Papadacci, Mathieu Pernot |
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| Přispěvatelé: | Physique pour la médecine (PhysMed Paris), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), IMRB - PROTECT/'Pharmacologie et Technologies pour les Maladies Cardiovasculaires' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Demeulenaere, Oscar, Physique pour la médecine (UMR 8063, U1273), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adenosine
[PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] ultrasound [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging imaging microcirculation volumetric imaging X-Ray Microtomography Coronary Vessels Rats [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Predictive Value of Tests Coronary Circulation microscopy [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] Animals blood flow Radiology Nuclear Medicine and imaging Cardiology and Cardiovascular Medicine [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] coronary |
| Zdroj: | JACC: Cardiovascular Imaging JACC: Cardiovascular Imaging, 2022, ⟨10.1016/j.jcmg.2022.02.008⟩ JACC: Cardiovascular Imaging, Elsevier/American College of Cardiology, 2022, ⟨10.1016/j.jcmg.2022.02.008⟩ |
| ISSN: | 1936-878X 1876-7591 |
| DOI: | 10.1016/j.jcmg.2022.02.008⟩ |
| Popis: | International audience; ObjectivesThe purpose of this study was to demonstrate 3-dimensional (3D) coronary ultrasound localization microscopy (CorULM) of the whole heart beyond the acoustic diffraction limit (1000 images/s).BackgroundDirect assessment of the coronary microcirculation has long been hampered by the limited spatial and temporal resolutions of cardiac imaging modalities.MethodsCorULM was performed in isolated beating rat hearts (N = 6) with ultrasound contrast agents (Sonovue, Bracco), using an ultrasonic matrix transducer connected to a high channel–count ultrafast electronics. We assessed the 3D coronary microvascular anatomy, flow velocity, and flow rate of beating hearts under normal conditions, during vasodilator adenosine infusion, and during coronary occlusion. The coronary vasculature was compared with micro-computed tomography performed on the fixed heart. In vivo transthoracic CorULM was eventually assessed on anaesthetized rats (N = 3).ResultsCorULM enables the 3D visualization of the coronary vasculature in beating hearts at a scale down to microvascular structures ( |
| Databáze: | OpenAIRE |
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