Reconstitution of the immune system and clinical correlates after stem cell transplantation for systemic sclerosis
| Autor: | Marianna Y, Kawashima-Vasconcelos, Maynara, Santana-Gonçalves, Djúlio C, Zanin-Silva, Kelen C R, Malmegrim, Maria Carolina, Oliveira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2022.941011 |
| Popis: | Systemic sclerosis (SSc) is a chronic autoimmune disease that includes fibrosis, diffuse vasculopathy, inflammation, and autoimmunity. Autologous hematopoietic stem cell transplantation (auto-HSCT) is considered for patients with severe and progressive SSc. In recent decades, knowledge about patient management and clinical outcomes after auto-HSCT has significantly improved. Mechanistic studies have contributed to increasing the comprehension of how profound and long-lasting are the modifications to the immune system induced by transplantation. This review revisits the immune monitoring studies after auto-HSCT for SSc patients and how they relate to clinical outcomes. This understanding is essential to further improve clinical applications of auto-HSCT and enhance patient outcomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|