Thoracic Kyphosis on Chest CT Scans Is Associated With Incident Vertebral Fractures in Smokers
| Autor: | Emiel F.M. Wouters, Paul C. Willems, Frank W.J.M. Smeenk, Piet Geusens, Joop P. W. van den Bergh, Mayke J. van Dort, Elisabeth A. P. M. Romme, Johanna H M Driessen |
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| Přispěvatelé: | Interne Geneeskunde, RS: NUTRIM - R3 - Respiratory & Age-related Health, RS: CAPHRI - R5 - Optimising Patient Care, MUMC+: DA KFT Medische Staf (9), RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, Orthopedie, MUMC+: MA Orthopedie (9), RS: SHE - R1 - Research (OvO), Onderwijs instituut FHML, MUMC+: MA Longziekten (3), Pulmonologie |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Endocrinology Diabetes and Metabolism Chest ct Kyphosis Pulmonary disease 030209 endocrinology & metabolism Thoracic kyphosis OBSTRUCTIVE PULMONARY-DISEASE Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine OSTEOPOROTIC FRACTURES medicine COPD PATIENTS Humans Orthopedics and Sports Medicine Aged COPD FRACTURE RISK ASSESSMENT business.industry Hazard ratio KYPHOSIS ANGLE WOMEN MEN Original Articles Middle Aged GLOBAL BURDEN medicine.disease BIOMECHANICS SCREENING Sagittal plane PREVALENCE 030104 developmental biology medicine.anatomical_structure Increased risk RISK-FACTORS Spinal Fractures Female Original Article BONE-DENSITY HYPERKYPHOTIC POSTURE business Nuclear medicine SMOKERS |
| Zdroj: | Journal of Bone and Mineral Research, 34(5), 859-866. Wiley Journal of Bone and Mineral Research |
| ISSN: | 1523-4681 0884-0431 |
| Popis: | Greater kyphosis angles lead to increased loading on vertebral bodies in computational models. However, results about the relationship between severity of kyphosis and incident vertebral fracture (VF) risk have been conflicting. Therefore, the aim of this study was to evaluate associations between 1) prevalent VFs and severity of kyphosis, and 2) severity of kyphosis and incident VF risk in smokers with or without chronic obstructive pulmonary disease (COPD). Former and current smokers with or without COPD were included. CT scans were made at baseline, 1-year, and 3-year follow-up. VFs were evaluated on superposed sagittal CT reconstructions. Kyphosis was measured as the angle between the lines above T-4 and below T-9 or T-12. We included 1239 subjects (mean age 61.3 +/- 8.0 years, 61.1% male, 80.6% with COPD), of whom 253 (20.4%) had a prevalent VF and 294 (23.7%) an incident VF within 3 years. Presence, number, and severity of prevalent VFs were associated with a greater kyphosis angle. The mean increase in kyphosis angle within 3 years was small but significantly greater in subjects with incident VFs compared with those without (2.2 +/- 4.1 versus 1.2 +/- 3.9 degrees, respectively, for T-4 to T-12 angle, p |
| Databáze: | OpenAIRE |
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