Efficacy and safety of direct-acting antiviral agents for HCV in mild-to-moderate chronic kidney disease
| Autor: | Fabrizio Fabrizi, Sami Aoufi-Rabih, Manuel Mendizabal, Rebeca García-Agudo, Ezequiel Ridruejo, Marcelo Silva, Vivek Dixit |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cyclopropanes
Male Pyrrolidines Sustained Virologic Response Hepacivirus lcsh:RC870-923 chemistry.chemical_compound Simeprevir 2-Naphthylamine purl.org/becyt/ford/3.2 [https] Medicine Anilides AAD Sulfonamides Dasabuvir Imidazoles Valine Hepatitis C Middle Aged Pibrentasvir Drug Combinations Grazoprevir Nephrology HCV Drug Therapy Combination Female purl.org/becyt/ford/3 [https] medicine.drug medicine.medical_specialty Elbasvir Genotype Proline Lactams Macrocyclic EGFR Antiviral Agents Quinoxalines Internal medicine CKD Humans Renal Insufficiency Chronic Uracil Benzofurans Gynecology Ritonavir business.industry Glecaprevir medicine.disease lcsh:Diseases of the genitourinary system. Urology Amides Ombitasvir chemistry Paritaprevir Benzimidazoles Carbamates Sofosbuvir business |
| Zdroj: | Nefrología (English Edition), Vol 40, Iss 1, Pp 46-52 (2020) Nefrología, Vol 40, Iss 1, Pp 46-52 (2020) CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 2013-2514 |
| Popis: | BACKGROUND AND AIMS:The advent of direct-acting antiviral agents promises to change the management of hepatitis C virus infection (HCV) in patients with chronic kidney disease (CKD), a patient group in which the treatment of hepatitis C was historically challenging. We investigated the safety and efficacy of all-oral, interferon-free direct-acting antiviral agents for the treatment of hepatitis C in a 'real-world' cohort of patients with CKD.METHODS:We performed an observational single-arm multi-centre study in a large (n=198) cohort of patients with stage 1-3 CKD who underwent antiviral therapy with DAAs for the treatment of HCV. The primary end-point was sustained virologic response (serum HCV RNA |
| Databáze: | OpenAIRE |
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