The fibroblastic nature of dermatofibrosarcoma protuberans. A tissue culture and ultrastructural study
| Autor: | Julio Escalona-Zapata, Emilio Alvarez Fernandez, Francisco Llorca Escuin |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Histology Skin Neoplasms Time Factors Fibrosarcoma Biology Cell morphology Pathology and Forensic Medicine law.invention Tissue culture law Culture Techniques medicine Dermatofibrosarcoma protuberans Neoplasm Humans Molecular Biology Aged Fibromatosis Cell Biology General Medicine Anatomy Fibroblasts Middle Aged medicine.disease Microscopy Electron Ultrastructure Female Electron microscope |
| Zdroj: | Virchows Archiv. A, Pathological anatomy and histology. 391(2) |
| ISSN: | 0340-1227 |
| Popis: | Dermatofibrosarcoma protuberans has been considered to be of fibrohistiocytic or fibroblastic origin. The purpose of this paper is to identify the original cell strain from which this neoplasm derives, using tissue culture and electron microscopic methods. Thirteen cases of DFSP characterised by clinical, topographical, histological and behavioral criteria were explanted. The emigrating cells were bipolar with two opposed processed and showed a radial arrangement in respect to the expiants. After the second week the distal processes tended to curve back towards the cell body forming flame-like structures. This cell morphology and cellular orientation persisted during the whole life of the culture. Electron microscopy was performed in three cases; the newly grown cells maintained an electron microscopic picture similar to that found in the original tumors. This pattern of behaviour is characteristic of fibroblastic tumors and has been found in explants of normal fibroblasts, of fibromatosis and of fibrosarcomas used as controls. On this basis, we believe that DFSP is a fibrosarcoma of the skin of low grade malignancy. |
| Databáze: | OpenAIRE |
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