| Autor: |
Xiaoli Min, Meiling Zheng, Yaqin Yu, Jiali Wu, Qiqi Kuang, Zhi Hu, Lianlian Ouyang, Shuang Lu, Ming Zhao |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Experimental dermatologyREFERENCES. 31(8) |
| ISSN: |
1600-0625 |
| Popis: |
Skin inflammation and photosensitivity are common in lupus erythematosus (LE) patients, and ultraviolet (UV) light is a known trigger of skin and possibly systemic inflammation in systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) patients. Type I interferons (IFN) are upregulated in LE skin after UV exposure; however, the mechanisms to explain UVB-induced inflammation remain unclear. Here, we demonstrated that UVB irradiation-induced activation of human endogenous retroviruses (HERVs) plays a major role in the immune response. UVB-induced HERV-associated dsRNA transcription and subsequent activation of the innate antiviral RIG-I/MDA5/IRF7 pathway led to downstream transcription of interferon-stimulated genes, which promotes UVB-induced apoptosis and proliferation inhibition in keratinocytes through RIG-I and MDA5 pathways. Our findings indicate that UVB irradiation induces HERV-dsRNA overexpression, and the dsRNA-sensing innate immunity pathway promotes type I IFN production, which may be a potential mechanism of skin inflammatory response and skin lesion of SLE/DLE. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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