Hepatotoxicity and genotoxicity of gasoline fumes in albino rats
| Autor: | J. S. Ashidi, Wasiu Eniola Olooto, G. A. Dedeke, A. A. Aladesida, Folarin O. Owagboriaye |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Pharmaceutical Science Medicine (miscellaneous) Physiology 010501 environmental sciences medicine.disease_cause 01 natural sciences 03 medical and health sciences Albino rats medicine Alanine aminotransferase lcsh:Science 0105 earth and related environmental sciences lcsh:R5-920 030505 public health Inhalation Chemistry Gasoline fumes Hepatotoxicity Diagnostic marker Agricultural and Biological Sciences (miscellaneous) RAPD Alkaline phosphatase Gasoline fume lcsh:Q Liver dysfunction Genotoxicity 0305 other medical science lcsh:Medicine (General) |
| Zdroj: | Beni-Suef University Journal of Basic and Applied Sciences, Vol 6, Iss 3, Pp 253-259 (2017) |
| ISSN: | 2314-8535 |
| Popis: | Toxic effects of gasoline fumes have been reported, but evidence of its hepatotoxicity and genotoxicity are rare. Therefore, this study assesses hepatotoxicity and genotoxicity of gasoline fumes on forty Albino rats randomly assigned to five experimental treatments (T) with eight rats per treatment (T1, T2, T3, T4 and T5). T1(Control) was housed in a section of experimental animal house free from gasoline fumes while T2, T3, T4 and T5 were exposed to gasoline fumes in exposure chambers for one, three, five and nine hours daily respectively for twelve weeks. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and histopathological examination of the liver tissues were used as diagnostic markers to assess liver dysfunction. Genotoxicity test was conducted on the lung tissues using randomly amplified polymorphic DNA fingerprinting polymerase chain reaction (RAPD PCR) technique. Significant increase (p |
| Databáze: | OpenAIRE |
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