Cutaneous Leishmaniosis caused by Leishmania martiniquensis in a Horse in Florida
| Autor: | M. Popielarczyk, Matti Kiupel, Monique Paiva de Campos, Rodrigo Caldas Menezes |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Pathology medicine.medical_specialty 040301 veterinary sciences Leishmaniasis Cutaneous Inflammation Biology 030308 mycology & parasitology Pathology and Forensic Medicine law.invention 0403 veterinary science 03 medical and health sciences law medicine Animals Parasite hosting Horses Amastigote Polymerase chain reaction Leishmania 0303 health sciences General Veterinary Horse 04 agricultural and veterinary sciences biology.organism_classification Basophilic Florida Immunohistochemistry Horse Diseases medicine.symptom |
| Zdroj: | Journal of Comparative Pathology. 173:13-18 |
| ISSN: | 0021-9975 |
| DOI: | 10.1016/j.jcpa.2019.09.011 |
| Popis: | Summary We report a new case of cutaneous leishmaniosis caused by Leishmania (Mundinia) martiniquensis in a horse in Florida, USA. A 10-year-old neutered male Quarter horse was presented with multifocal to coalescing, raised, ulcerated and oozing, non-healing wounds on both pinnae of several weeks' duration. After a few months, the lesions regressed spontaneously. Biopsies of the lesions were performed with microscopical findings of epidermal hyperplasia with multifocal ulceration and focally extensive, dermal pyogranulomatous inflammation with numerous intact and degenerate neutrophils being surrounded by epithelioid macrophages, lymphocytes and plasma cells, as well as rare eosinophils. Within the macrophages, and freely within the inflammatory infiltrate, were small (2–4 μm) round, basophilic protozoal organisms. Immunohistochemistry and colourimetric in-situ hybridization were positive for amastigote forms of Leishmania spp. The species L. martiniquensis was identified by polymerase chain reaction targeting the ITS-1 gene performed with extracts from formalin-fixed and paraffin wax-embedded samples of skin lesions. L. martiniquensis causes an ulcerative pyogranulomatous dermatitis in horses with spontaneous healing. This second autochthonous case in Florida, 5 years after the first case, suggests that this parasite may have become endemic in this state. |
| Databáze: | OpenAIRE |
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