Characterizing the coalescence area of conjoined twins to elucidate congenital disorders in singletons
| Autor: | Annelieke N. Schepens-Franke, Roelof-Jan Oostra, Eduard Winter, Lucas L. Boer |
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| Přispěvatelé: | Medical Biology, ACS - Amsterdam Cardiovascular Sciences, ARD - Amsterdam Reproduction and Development |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Histology Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] sirenomelia Viewpoint Holoprosencephaly Conjoined twins medicine Cadaver Humans Abnormalities Multiple Coalescence (chemistry) Twins Conjoined business.industry concomitant anomalies Other Research Radboud Institute for Health Sciences [Radboudumc 0] General Medicine Aplasia medicine.disease Viewpoints holoprosencephaly neural tube defects Evolutionary biology Sirenomelia conjoined twins Anatomy business OEIS |
| Zdroj: | Clinical Anatomy (New York, N.y.) Clinical Anatomy, 34, 845-858 Clinical anatomy (New York, N.Y.), 34(6), 845-858. Wiley-Liss Inc. Clinical Anatomy, 34, 6, pp. 845-858 |
| ISSN: | 1098-2353 0897-3806 |
| Popis: | Contains fulltext : 238607.pdf (Publisher’s version ) (Open Access) Shared anomalies, always located close to the area of coalescence and observable in virtually every type of conjoined twinning, are currently seen as separate anomalies caused by mostly unknown and seemingly unrelated pathways rather than being connected to the twinning mechanism itself. Therefore, most (case) reports about conjoined twins are mere descriptions of (external) dysmorphologies lacking reflections on the possible origin of their concomitant anomalies. As we will demonstrate in this article, shared anomalies are influenced, and in some cases solely and sequentially explained, by interaction aplasia and neo-axial orientation; two embryological mechanisms to which each set of conjoined twins is subjected and are responsible for their ultimate phenotypical fate. In this review, we consider how the ventral, lateral and caudal conjunction types and their intermediates determine the phenotypic presentation of the twins, including patterns of shared malformations and anomalies, which in themselves can be indistinguishable from those encountered in singleton cases. Hence, it can be hypothesized that certain anomalies in singletons originate in a fashion similar to that in conjoined twins. |
| Databáze: | OpenAIRE |
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