Clinical features of organizing pneumonia associated with rheumatoid arthritis
| Autor: | H. Okada, Ayae Tanaka, Takayoshi Owada, Yoshiki Ishii, Reika Maezawa, Kazuhiro Kurasawa, Ryutaro Yamazaki, Satoko Arai |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Cross-sectional study Biopsy Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Rheumatology Recurrence Internal medicine Prevalence medicine Humans Glucocorticoids Pathological Aged 030203 arthritis & rheumatology biology medicine.diagnostic_test business.industry Medical record C-reactive protein Middle Aged medicine.disease Surgery C-Reactive Protein Cross-Sectional Studies Treatment Outcome 030228 respiratory system Cryptogenic Organizing Pneumonia Rheumatoid arthritis biology.protein Female Organizing pneumonia business |
| Zdroj: | Modern Rheumatology. 26:863-868 |
| ISSN: | 1439-7609 1439-7595 |
| DOI: | 10.3109/14397595.2016.1153217 |
| Popis: | To clarify the clinical features of organizing pneumonia (OP) associated with rheumatoid arthritis (RA) and to determine whether development of OP is related to RA activity.A cross-sectional study was conducted, in which medical records of 499 consecutive RA patients who visited our hospital during one month were reviewed. OP was diagnosed by pathological findings by trans-bronchial biopsy or by clinical features (typical computed tomography findings, no causative agents, good response to glucocorticoids, and lack of response to antibiotics).Among 499 patients, OP was found in 19 patients and the estimated prevalence was 1.9-4.8%. No differences in clinical features were noted between the OP and non-OP groups. The mean age of OP development was 57.2 years and the period from the onset of RA to OP ranged from -4 to +34 years. Although 14 patients presented OP after the onset of RA, two developed OP before RA and three developed OP simultaneously with RA. Patients receiving tumor necrosis factor inhibitors also developed OP. RA disease activity just before onset of OP was low in 8 of 14 RA cases. At the onset of OP, only two patients showed exacerbations of arthritis, whereas most patients presented with fever and serum C-reactive protein (CRP) elevations. Glucocorticoids were effective for OP in all patients who received them. Relapse occurred in 4 of 19 cases.OP develops in approximately 4% of RA patients, which occurs independently from arthritis activity and at any time in RA patients. |
| Databáze: | OpenAIRE |
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