Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
| Autor: | Mazumder, Atiqul Haq, Barnett, Jennifer, Isometsä, Erkki Tapio, Lindberg, Nina, Torniainen-Holm, Minna, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kerkelä, Martta, Ahola-Olli, Ari, Hietala, Jarmo, Kampman, Olli, Kieseppä, Tuula, Jukuri, Tuomas, Häkkinen, Katja, Cederlöf, Erik, Haaki, Willehard, Kajanne, Risto, Wegelius, Asko, Männynsalo, Teemu, Niemi-Pynttäri, Jussi, Suokas, Kimmo, Lönnqvist, Jouko, Tiihonen, Jari, Paunio, Tiina, Vainio, Seppo Juhani, Palotie, Aarno, Niemelä, Solja, Suvisaari, Jaana, Veijola, Juha |
|---|---|
| Přispěvatelé: | Mazumder, Atiqul Haq [0000-0002-2148-4070], Isometsä, Erkki Tapio [0000-0001-5956-2399], Torniainen-Holm, Minna [0000-0003-2149-855X], Lähteenvuo, Markku [0000-0002-7244-145X], Kerkelä, Martta [0000-0002-1181-2632], Ahola-Olli, Ari [0000-0002-4451-3487], Hietala, Jarmo [0000-0002-3179-6780], Kampman, Olli [0000-0001-6891-2266], Häkkinen, Katja [0000-0001-8222-7505], Haaki, Willehard [0000-0002-2850-7650], Kajanne, Risto [0000-0002-3405-7115], Suokas, Kimmo [0000-0001-6296-6343], Tiihonen, Jari [0000-0002-0400-6798], Paunio, Tiina [0000-0002-5560-0666], Vainio, Seppo Juhani [0000-0001-9319-3566], Palotie, Aarno [0000-0002-2527-5874], Niemelä, Solja [0000-0003-1130-9161], Suvisaari, Jaana [0000-0001-7167-0990], Veijola, Juha [0000-0002-4139-9981], Apollo - University of Cambridge Repository, Department of Psychiatry, HUS Psychiatry, University of Helsinki, Clinicum, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, Staff Services, Centre of Excellence in Complex Disease Genetics, Research Programme of Molecular Medicine, Aarno Palotie / Principal Investigator |
| Rok vydání: | 2021 |
| Předmět: |
cognition
Hazardous drinking Schizoaffective disorder Bipolar disorder Neurosciences. Biological psychiatry. Neuropsychiatry Article MODERATE ALCOHOL-USE 3124 Neurology and psychiatry Cognition DEPENDENCE COHORT RISK OLDER Reaction time reaction time bipolar disorder 3112 Neurosciences CONSUMPTION PERFORMANCE COGNITIVE IMPAIRMENT schizoaffective disorder hazardous drinking LIFE schizophrenia Schizophrenia PGS Visual memory visual memory MIDLIFE RC321-571 |
| Zdroj: | Brain Sciences, Vol 11, Iss 1422, p 1422 (2021) Brain Sciences Volume 11 Issue 11 |
| DOI: | 10.17863/cam.77480 |
| Popis: | The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|