The Allergist's Role in Detection of Severe Alpha-1 Antitrypsin Deficiency
| Autor: | Theodore E. Kelbel, Maria Paula Henao, Timothy J. Craig, Deirdre Walker, Darren Morris |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Spirometry Pediatrics medicine.medical_specialty Allergy Adolescent Population Disease Pulmonary Disease Chronic Obstructive Young Adult 03 medical and health sciences Allergists 0302 clinical medicine Surveys and Questionnaires alpha 1-Antitrypsin Deficiency medicine Humans Immunology and Allergy 030212 general & internal medicine Diagnostic Errors Child Physician's Role education Aged Asthma Aged 80 and over education.field_of_study COPD Alpha 1-antitrypsin deficiency medicine.diagnostic_test business.industry Middle Aged medicine.disease 030228 respiratory system Physical therapy Female business |
| Zdroj: | The Journal of Allergy and Clinical Immunology: In Practice. 5:1302-1306 |
| ISSN: | 2213-2198 |
| DOI: | 10.1016/j.jaip.2017.01.008 |
| Popis: | Background Alpha-1 antitrypsin deficiency (AATD) frequently presents as difficult to manage asthma or asthma with fixed obstruction and is well documented as being underdiagnosed in the population. Objective This study aimed to better describe allergists'/immunologists' involvement in the care of patients with AATD and whether they currently contribute to the underdiagnosis by lack of screening for the condition. Methods Using the Research Electronic Data Capture tool, we submitted a questionnaire to 500 patients with severe AATD (ZZ, SZ, ZNull, and FZ) through the Alpha-1 Foundation Research Registry to collect information about patient diagnosis and treatment patterns. Approximately 45% completed the questionnaire, leading to a final enrollment of 226 participants. Results Seventy-eight participants (34%) had seen an allergist, but only 11 (5%) were diagnosed with AATD by their allergist. Likewise, allergists prescribed alpha-1 augmentation therapy to only 5 (8%) of the 59 patients on augmentation therapy. Nearly 46% (n = 104) of all participants were diagnosed with either asthma (28%) or allergic disease (18%) before receiving a diagnosis of AATD. Eighteen patients had been treated with immunotherapy before their diagnosis of AATD, with 94% of these participants receiving treatment for 3 years or longer. Conclusions Our data suggest that specialists in Allergy and Immunology should consider and screen for AATD in patients with asthma in whom spirometry does not return to normal. Furthermore, we propose allergists/immunologists are well suited to screen and treat patients with AATD. |
| Databáze: | OpenAIRE |
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