A revised map of chromosome 1

Autor:	J. King, E. B. Robson, S. Yee, Stephanie L. Sherman
Rok vydání:	1984
Předmět:	Genetic Markers Male Recombination Genetic Genetics Genetic Linkage Maximum likelihood Chromosomes Human 1-3 Chromosome Mapping Chiasma Chromosome (genetic algorithm) Biological variation Humans Female Pairwise comparison Lod Score Algorithm Genetics (clinical) Mathematics Lod scores
Zdroj:	Annals of Human Genetics. 48:243-251
ISSN:	1469-1809 0003-4800
Popis:	Summary The genetic map of chromosome 1 reported by Keats, Morton & Rao (1981) has been updated using recent recombination data and regional assignments from the Galton Laboratory (King, 1982a) and from the current literature. A maximum likelihood mapping technique using pairwise recombination data without a chiasma map was developed, based on the principles of Rao et al. (1979) and Keats et al. (1981). The development of this new method was found to be necessary when inconsistencies were encountered using a method which combines recombination data and physical data through the chiasma map. These inconsistencies could be due to appreciable chiasma movement, incorrect physical assignments or technical and biological variation in lod scores.
Databáze:	OpenAIRE
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