Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep
| Autor: | Kyle K. Morgan, Don M. Tucker, Megan Carson, Evan Hathaway, Mariano Fernández-Corazza, Roma Shusterman, Phan Luu |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Slow oscillations Stimulation Electroencephalography Audiology Sleep Slow-Wave Transcranial Direct Current Stimulation Placebo Article 03 medical and health sciences 0302 clinical medicine Memory Slow wave sleep Humans Medicine EEG Slow-wave sleep Sleep Stages medicine.diagnostic_test business.industry food and beverages General Medicine Limbic lobe Sleep in non-human animals 030228 respiratory system Duration (music) Sleep Deep sleep business 030217 neurology & neurosurgery |
| Zdroj: | Sleep medicine |
| ISSN: | 1389-9457 |
| DOI: | 10.1016/j.sleep.2021.03.001 |
| Popis: | Background Researchers have proposed that impaired sleep may be a causal link in the progression from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD). Several recent findings suggest that enhancing deep sleep (N3) may improve neurological health in persons with MCI, and buffer the risk for AD. Specifically, Transcranial Electrical Stimulation (TES) of frontal brain areas, the inferred source of the Slow Oscillations (SOs) of N3 sleep, can extend N3 sleep duration and improve declarative memory for recently learned information. Recent work in our laboratory using dense array Electroencephalography (dEEG) localized the sources of SOs to anterior limbic sites – suggesting that targeting these sites with TES may be more effective for enhancing N3. Methods For the present study, we recruited 13 healthy adults (M = 42 years) to participate in three all-night sleep EEG recordings where they received low level (0.5 mA) TES designed to target anterior limbic areas and a sham stimulation (placebo). We used a convolutional neural network, trained and tested on professionally scored EEG sleep staging, to predict sleep stages for each recording. Results When compared to the sham session, limbic-targeted TES significantly increased the duration of N3 sleep. TES also significantly increased spectral power in the 0.5–1 Hz frequency band (relative to pre-TES epochs) in left temporoparietal and left occipital scalp regions compared to sham. Conclusion These results suggest that even low-level TES, when specifically targeting anterior limbic sites, can increase deep (N3) sleep and thereby contribute to healthy sleep quality. |
| Databáze: | OpenAIRE |
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