Multiplexed Dendritic Targeting of α Calcium Calmodulin-dependent Protein Kinase II, Neurogranin, and Activity-regulated Cytoskeleton-associated Protein RNAs by the A2 Pathway
| Autor: | Mikhail K. Levin, John H. Carson, George Korza, Yuanzheng Gao, Vedakumar Tatavarty |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Heterogeneous nuclear ribonucleoprotein
Molecular Sequence Data RNA transport Nerve Tissue Proteins Plasma protein binding Cytoplasmic Granules Response Elements Antibodies RNA Transport Rats Sprague-Dawley Mice Gene expression Heterogeneous-Nuclear Ribonucleoprotein Group A-B Animals Neurogranin Molecular Biology Conserved Sequence Electroshock biology Base Sequence RNA Cell Biology Articles Dendrites Myelin basic protein Rats Cytoskeletal Proteins Biochemistry Synaptic plasticity biology.protein Calcium-Calmodulin-Dependent Protein Kinase Type 2 Protein Binding Subcellular Fractions |
| Popis: | In neurons, many different RNAs are targeted to dendrites where local expression of the encoded proteins mediates synaptic plasticity during learning and memory. It is not known whether each RNA follows a separate trafficking pathway or whether multiple RNAs are targeted to dendrites by the same pathway. Here, we show that RNAs encoding α calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein are coassembled into the same RNA granules and targeted to dendrites by the same cis/trans-determinants (heterogeneous nuclear ribonucleoprotein [hnRNP] A2 response element and hnRNP A2) that mediate dendritic targeting of myelin basic protein RNA by the A2 pathway in oligodendrocytes. Multiplexed dendritic targeting of different RNAs by the same pathway represents a new organizing principle for coordinating gene expression at the synapse. |
| Databáze: | OpenAIRE |
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