Extracellular Calcium Causes the Release of Calcium from Intracellular Stores in Chick Osteocytes
| Autor: | Kahori Tagami, Kazuo Hosoi, Koji Sumitani, Yoshiki Miki, Terushige Kawata, Hiroshi Kamioka, Kunihiro Terai |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
TRPV6
Nifedipine Calcium pump Biophysics chemistry.chemical_element Chick Embryo Calcium Osteocytes Biochemistry Calcium in biology Nicardipine Cytosol Gallic Acid Animals Molecular Biology Calcium metabolism Chemistry Calcium channel T-type calcium channel Cell Biology 3-Pyridinecarboxylic acid 1 4-dihydro-2 6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl ester Calcium Channel Blockers Calcium ATPase |
| Zdroj: | Biochemical and Biophysical Research Communications. 212:692-696 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1995.2024 |
| Popis: | We have recently demonstrated that a rise in the extracellular divalent cation concentration induces a rapid elevation of cytosolic calcium in chick osteocytes. Here, we demonstrate that cytosolic calcium elevation that occurs in osteocytes on exposure to elevated extracellular calcium is independent of membrane voltage and is insensitive to modulation by organic calcium channel modulators, namely, BAY K 8644, nicardipine, and nifedipine. However, the calcium elevation was sensitive to modulation by an intracellular calcium antagonist, TMB-8, suggesting that the cytosolic calcium elevation was due to mobilization of this cation from an intracellular store. |
| Databáze: | OpenAIRE |
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