Serum and vitreous vascular endothelial growth factor levels in diabetic retinopathy
| Autor: | Goncagul Haklar, Osman Çekiç, Fatma Işıl Sözen-Delil |
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| Přispěvatelé: | Sozen-Delil F. I., Cekic O., HAKLAR G. |
| Rok vydání: | 2022 |
| Předmět: |
Vitreous humor
Sağlık Bilimleri Göz Hastalıkları ve Cerrahisi Clinical Medicine (MED) Oftalmoloji Eye Diseases and Surgery Diabetic retinopathy Surgery Medicine Sciences Ranibizumab Health Sciences Klinik Tıp (MED) EYES Klinik Tıp GÖZ HASTALIKLARI CLINICAL MEDICINE FLUID Tıp Optometri Bevacizumab Ophthalmology Cerrahi Tıp Bilimleri INTRAVITREAL BEVACIZUMAB Medicine Triamcinolone acetonide Vascular endothelial growth factor INJECTION Optometry |
| Zdroj: | International Ophthalmology. |
| ISSN: | 1573-2630 |
| DOI: | 10.1007/s10792-022-02620-y |
| Popis: | Purpose To research whether serum vascular endothelial growth factor (VEGF) levels could be used to evaluate diabetic retinopathy (DR) progression and to compare vitreous VEGF levels after injections of intravitreal bevacizumab (IVB), ranibizumab (IVR), and triamcinolone acetonide (IVTA) in proliferative diabetic retinopathy (PDR). Methods We enrolled a total of 91 eyes of 89 subjects (70 eyes of 68 diabetics and 21 eyes of 21 nondiabetic controls). The diabetic subjects were divided into three groups as PDR (n=28), non-proliferative diabetic retinopathy (n=20), and no-DR (n=20). Eyes with PDR (n=31) were injected with IVB (n=7), IVR (n=10), or IVTA (n=6) 3 days before vitrectomy, and eight eyes did not receive an injection. Serum and vitreous samples were collected before vitrectomy and analyzed using ELISA. Results We found the severity of retinopathy was not correlated with serum VEGF levels (P=.919, ρ=−0.011). Compared with the controls, vitreous VEGF was higher in the PDR (P |
| Databáze: | OpenAIRE |
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