Circadian rhythms in liver metabolism and disease

Autor: John Y.L. Chiang, Jessica M. Ferrell
Jazyk: angličtina
Rok vydání: 2015
Předmět:
CRY
cryptochrome

FEO
food entrainable oscillator

TGR5
G protein-coupled bile acid receptor

Disease
Type 2 diabetes
Review
Shift work
SHP
small heterodimer partner

NAD+
nicotinamide adenine dinucleotide

LDL
low-density lipoprotein

CYPs
cytochrome P450 enzymes

HLF
hepatic leukemia factor

BMAL1
brain and muscle ARNT-like 1

HIP
hypoxia inducing protein

General Pharmacology
Toxicology and Pharmaceutics

RORα
retinoid-related orphan receptor α

FOXO3
forkhead box O3

RHT
retinohypothalamic tract

Circadian rhythm
CLOCK
circadian locomotor output cycles kaput

GLUT2
glucose transporter 2

Sleep in non-human animals
Metabolic syndrome
RORE
ROR-response element

Liver
CAR
constitutive androstane receptor

E-box
enhance box

medicine.medical_specialty
SIRT1
sirtuin 1

DBP
D-site binding protein

PER
period

TEF
thyrotroph embryonic factor

ARC
arcuate nucleus

Internal medicine
LRH1
liver receptor homolog 1

medicine
FXR
farnesoid-X receptor

SCN
suprachiasmatic nucleus

business.industry
lcsh:RM1-950
HDAC3
histone deacetylase 3

EMT
emergency medical technician

FASPS
familial advanced sleep-phase syndrome

medicine.disease
CYP7A1
cholesterol 7α-hydroxylase

Obesity
lcsh:Therapeutics. Pharmacology
Endocrinology
TTFL
transcriptional translational feedback loop

FAA
food anticipatory activity

business
Dyslipidemia
Zdroj: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 2, Pp 113-122 (2015)
ISSN: 2211-3843
2211-3835
Popis: Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, type 2 diabetes and dyslipidemia. Here, these associations are reviewed with respect to liver metabolism and disease.
Graphical abstract Shift work, chronic jet lag, and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, Type 2 diabetes and dyslipidemia. Here, these associations are reviewed with respect to liver metabolism and disease.
Databáze: OpenAIRE