Pancytopenia with myelodysplasia due to copper deficiency
| Autor: | John Lazarchick, Michelle Hudspeth, Jocelyn A. Lewis, Lauren B. Angotti, Ginell R. Post, Nancy S. Robinson |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Short Bowel Syndrome medicine.medical_specialty Myeloid Malabsorption Anemia Pancytopenia Gastroenterology Enterocolitis Necrotizing hemic and lymphatic diseases Internal medicine medicine Humans Neural Tube Defects medicine.diagnostic_test business.industry Infant Hematology medicine.disease Short bowel syndrome Bone marrow examination medicine.anatomical_structure Oncology Pediatrics Perinatology and Child Health Immunology Parenteral Nutrition Total Macrocytic anemia business Copper deficiency Copper |
| Zdroj: | Pediatric bloodcancer. 51(5) |
| ISSN: | 1545-5017 |
| Popis: | We present a case of pancytopenia in a 9-month-old infant with total parenteral nutrition (TPN) dependence due to short bowel syndrome. Bone marrow examination revealed left-shifted myeloid maturation, erythroid and myeloid dysplasia with normal iron stores. Serum copper level was 2 microm/dl (normal range 90-190 mcg/dl). After supplementation, copper levels normalized at 143 mcg/dl, and the macrocytic anemia, neutropenia, and thrombocytopenia resolved. Copper deficiency should be considered in the differential diagnosis of cytopenias and myelodsyplasia, particularly in the growing number of pediatric patients with TPN dependency or malabsorption. |
| Databáze: | OpenAIRE |
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