Dialkyl Bisphosphonate Platinum(II) Complex as a Potential Drug for Metastatic Bone Tumor
| Autor: | Asami Yamaguchi, Hisao Ekimoto, Hidetoshi Nakatake, Mariko Aso, Hiroshi Suemune, Atsushi Ogawa |
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| Rok vydání: | 2011 |
| Předmět: |
endocrine system diseases
Stereochemistry medicine.medical_treatment Osteoclasts chemistry.chemical_element Antineoplastic Agents Bone Neoplasms Bone resorption Carboplatin chemistry.chemical_compound Coordination Complexes Osteoclast Cell Line Tumor Drug Discovery medicine Humans Neoplasm Metastasis Platinum Cisplatin Diphosphonates Ligand General Chemistry General Medicine Bisphosphonate female genital diseases and pregnancy complications Durapatite medicine.anatomical_structure chemistry Cancer research Adsorption medicine.drug Conjugate |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 59:710-713 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Bisphosphonates have high affinity for hydroxyapatite (HA), which is abundantly present in bone. Also, platinum complexes are known that have a wide spectrum of antitumor activities. The conjugate of bisphosphonate and a platinum complex might have HA affinity and antitumor activity, and become a drug for metastatic bone tumor. In this study, the authors synthesized platinum complexes that had dialkyl bisphosphonic acid as a ligand, and evaluated the possibility of the synthesized complexes as a drug for metastatic bone tumor. The synthesized dialkyl bisphosphonate platinum(II) complex was characterized, and its stability in an aqueous solution was also confirmed. The synthesized platinum complex showed higher HA affinity than other platinum complexes such as cisplatin and carboplatin in an experiment of adsorption to HA. In vitro, the platinum complex showed tumor growth inhibitory effect stronger than or equal to cisplatin, which is the most commonly used antitumor agent. Moreover, the platinum complex showed a bone absorption inhibitory effect on the osteoclast. These results suggest potential of dialkyl bisphosphonate platinum(II) complexes as a drug for metastatic bone tumor. |
| Databáze: | OpenAIRE |
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