AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper
| Autor: | Debra H. Josephs, Karin Hartmann, Manuel L. Penichet, Erika Jensen-Jarolim, Luca Vangelista, Sophia N. Karagiannis, Liam O'Mahony, Rodolfo Bianchini, Hannah J. Gould, Eva Untersmayr, Francesca Levi-Schaffer, Heather J. Bax, Christoph Bergmann, Michelle C. Turner, Franziska Roth-Walter, Wendy Cozen, Frank A. Redegeld, Aurélie Poli |
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| Přispěvatelé: | Afd Pharmacology, Pharmacology |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Allergy Disease hygiene hypothesis Epithelium Immune tolerance 0302 clinical medicine oncoimmunology Neoplasms Immunology and Allergy Medicine Micronutrients Child Phylogeny Cancer Immunity Cellular Microbiota 3. Good health Child Preschool Female Oncoimmunology Position Paper Immunology 03 medical and health sciences Immune system Hygiene hypothesis Immunity microbiota cancer Animals Humans Microbiome Mucous Membrane Bacteria Host Microbial Interactions business.industry Infant biochemical phenomena metabolism and nutrition medicine.disease allergy Asthma Diet Gastrointestinal Microbiome 030104 developmental biology 030228 respiratory system Hygience hypothesis bacteria business |
| Zdroj: | Allergy Allergy, 74(6), 1037. Blackwell Publishing Ltd Untersmayr, E, Bax, H J, Bergmann, C, Bianchini, R, Cozen, W, Gould, H J, Hartmann, K, Josephs, D H, Levi-Schaffer, F, Penichet, M L, O'Mahony, L, Poli, A, Redegeld, F A, Roth-Walter, F, Turner, M C, Vangelista, L, Karagiannis, S N & Jensen-Jarolim, E 2019, ' AllergoOncology: Microbiota in allergy and cancer : a European Academy for Allergy and Clinical Immunology position paper ', Allergy, vol. 74, no. 6, pp. 1037-1051 . https://doi.org/10.1111/all.13718 |
| ISSN: | 1398-9995 0105-4538 |
| Popis: | The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti‐ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune‐related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome. |
| Databáze: | OpenAIRE |
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