Acetylcholinesterase inhibitors to enhance recovery from traumatic brain injury: a comprehensive review and case series

Autor:	Samuel A Florentino, Mohammad H Bawany, Heather M Ma
Rok vydání:	2022
Předmět:	Adult Piperidines Galantamine Brain Injuries Traumatic Acetylcholinesterase Neuroscience (miscellaneous) Developmental and Educational Psychology Humans Donepezil Rivastigmine Cholinesterase Inhibitors Neurology (clinical) Child
Zdroj:	Brain Injury. 36:441-454
ISSN:	1362-301X 0269-9052
Popis:	Acetylcholinesterase inhibitors (AChEIs) are used off-label, in both adult and pediatric patients, to help further neuro-recovery after traumatic brain injury (TBI). Evidence is limited and piecemeal. This review describes how TBI affects the cholinergic system and consolidates evidence supporting or refuting the use of AChEIs following TBI.NCBI MEDLINE search included all articles published through March 2021 on AChEI use in acute and post-acute adult TBI rehabilitation (treatment began90 days or ≥90 days since injury, respectively), and in pediatric TBI rehabilitation. Further, we checked27 original articles from NCBI Medline, published through March 2021, were included. The use of AChEIs following TBI in acute and post-acute rehabilitation settings, in both adult and pediatric patients, along with medication side effects, is discussed.Most studies showed benefits with only moderate effect sizes because of small sample sizes. Reported side effects are minimal and stop soon after AChEIs is discontinued. Conclusions are limited by paucity of research; but fortunately, a large randomized controlled trial is ongoing, and more are needed to truly determine the efficacy of AChEIs in helping with recovery from TBI.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8688d670d3def89971b52d2d571abd56 https://doi.org/10.1080/02699052.2022.2034962 Zobrazit plný text záznamu