Naringin@Metal–Organic Framework as a Multifunctional Bioplatform
| Autor: | Xueying Ge, Fangchao Jiang, Minghui Wang, Meng Chen, Yiming Li, Joshua Phipps, Jianfeng Cai, Jin Xie, Jane Ong, Viktor Dubovoy, James G. Masters, Long Pan, Shengqian Ma |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | ACS Applied Materials & Interfaces. 15:677-683 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.2c19904 |
| Popis: | Naringin, a natural product, can be used as a therapeutic agent due to its low systemic toxicity and negligible adverse effect. However, due to its hydrophobic nature and thereby low solubility, high-dose treatment is required when used for human therapy. Herein, we demonstrate the employment of a metal-organic framework (MOF) as a nontoxic loading carrier to encapsulate naringin, and the afforded nairngin@MOF composite can serve as a multifunctional bioplatform capable of treating Gram-positive bacteria and certain cancers by slowly and progressively releasing the encapsulated naringin as well as improving and modulating immune system functions through synergy between naringin and the MOF. |
| Databáze: | OpenAIRE |
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