Systematic evaluation of non-animal test methods for skin sensitisation safety assessment
| Autor: | Dirk Petersohn, Martina Klaric, Andreas Natsch, Valentina Galbiati, Takao Ashikaga, Nathalie Alépée, Andreas Schepky, Gavin Maxwell, Marion Millet, Marie Templier, Donald Keller, Nathalie Lambrechts, Magalie Tailhardat, Nicola Gellatly, Erwin van Vliet, Ian Pike, Jalila Hibatallah, Petra S. Kern, Malin Lindstedt, Sebastian Hoffmann, Hervé Groux, Kerstin Reisinger, Cliff Elcombe, João Barroso, Hitoshi Sakaguchi, Jochen Kuehnl, Silvia Martinozzi-Teissier, Susan Gibbs, Susanne N. Kolle |
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| Přispěvatelé: | Orale Celbiologie (ORM, ACTA), Oral Cell Biology, Dermatology, MOVE Research Institute, CCA - Innovative therapy |
| Jazyk: | angličtina |
| Předmět: |
Test strategy
Keratinocytes Computer science media_common.quotation_subject Cosmetics In Vitro Techniques computer.software_genre Animal Testing Alternatives Toxicology Risk Assessment Cell Line SDG 17 - Partnerships for the Goals Humans media_common Skin Adverse Outcome Pathways Task force Interleukin-18 Non-animal test methods General Medicine Test method U937 Cells Skin sensitisation Test (assessment) Risk analysis (engineering) Safety assessment Dermatitis Allergic Contact Epidermis Risk assessment Testing strategy computer Test data Data integration |
| Zdroj: | Toxicology in vitro, 29(1), 259-270. Elsevier Toxicology in Vitro, 29(1), 259-270. Elsevier Limited Europe PubMed Central Reisinger, K, Hoffmann, S, Alepee, N, Ashikaga, T, Barroso, J, Elcombe, C, Gellatly, N, Galbiati, V, Gibbs, S, Groux, H, Hibatallah, J, Keller, D, Kern, P, Klaric, M, Kolle, S, Kuehnl, J, Lambrechts, N, Lindstedt, M, Millet, M, Martinozzi-Teissier, S, Natsch, A, Petersohn, D, Pike, I, Sakaguchi, H, Schepky, A, Tailhardat, M, Templier, M, van Vliet, E & Maxwell, G 2015, ' Systematic evaluation of non-animal test methods for skin sensitisation safety assessment ', Toxicology in Vitro, vol. 29, no. 1, pp. 259-270 . https://doi.org/10.1016/j.tiv.2014.10.018 Reisinger, K, Hoffmann, S, Alépée, N, Ashikaga, T, Barroso, J, Elcombe, C, Gellatly, N, Galbiati, V, Gibbs, S, Groux, H, Hibatallah, J, Keller, D, Kern, P, Klaric, M, Kolle, S, Kuehnl, J, Lambrechts, N, Lindstedt, M, Millet, M, Martinozzi-Teissier, S, Natsch, A, Petersohn, D, Pike, I, Sakaguchi, H, Schepky, A, Tailhardat, M, Templier, M, van Vliet, E & Maxwell, G 2015, ' Systematic evaluation of non-animal test methods for skin sensitisation safety assessment ', Toxicology in Vitro, vol. 29, no. 1, pp. 259-270 . https://doi.org/10.1016/j.tiv.2014.10.018 |
| ISSN: | 0887-2333 |
| DOI: | 10.1016/j.tiv.2014.10.018 |
| Popis: | The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitisation potency prediction. The results of the first phase – systematic evaluation of 16 test methods – are presented here. This evaluation involved generation of data on a common set of ten substances in all methods and systematic collation of information including the level of standardisation, existing test data, potential for throughput, transferability and accessibility in cooperation with the test method developers. A workshop was held with the test method developers to review the outcome of this evaluation and to discuss the results. The evaluation informed the prioritisation of test methods for the next phase of the non-animal testing strategy development framework. Ultimately, the testing strategy – combined with bioavailability and skin metabolism data and exposure consideration – is envisaged to allow establishment of a data integration approach for skin sensitisation safety assessment of cosmetic ingredients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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