Comparison of Clinicopathological Features of Biliary Neuroendocrine Carcinoma with Adenocarcinoma
Autor: | Masakazu Yamamoto, Ryota Higuchi, Wataru Izumo, Masahiro Shiihara, Toru Furukawa, Takehisa Yazawa, Shuichiro Uemura |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male medicine.medical_specialty Kaplan-Meier Estimate Gastroenterology Metastasis Cholangiocarcinoma Bile Ducts Extrahepatic Internal medicine Medicine Humans Neuroendocrine carcinoma Risk factor Pathological Aged Retrospective Studies Aged 80 and over business.industry Bile duct Hazard ratio Cancer Middle Aged medicine.disease Prognosis digestive system diseases Carcinoma Neuroendocrine medicine.anatomical_structure Bile Duct Neoplasms Adenocarcinoma Surgery Female business |
Zdroj: | Digestive surgery. 38(1) |
ISSN: | 1421-9883 |
Popis: | Objective: This study aimed to demonstrate the clinical features and postoperative outcomes of extrahepatic bile duct (EHBD) neuroendocrine carcinoma (NEC) and compared with those of adenocarcinoma. Methods: We retrospectively analyzed patients with EHBD cancer operated in our institution between 1995 and 2015. Results: Of 475 patients, 468 had adenocarcinoma, while 7 had NEC/mixed adenoneuroendocrine carcinoma (MANEC) in this study. There were no notable preoperative and pathological features in patients with NEC/MANEC. However, patients with NEC/MANEC had a higher recurrence rate (51.8 vs. 100%, p = 0.016), poorer relapse-free survival (RFS) time (the median RFS time: 35 vs. 12 months, p = 0.006), and poorer overall survival (OS) time (the median OS time: 60 vs. 19 months, p = 0.078) than those with adenocarcinoma. Furthermore, patients with NEC/MANEC had higher rates of liver metastasis (11.9 vs. 85.7%, p < 0.001) than those with adenocarcinoma. In multivariable regression analysis, pathological type with NEC/MANEC was a risk factor for poorer RFS (p = 0.022, hazard ratio: 6.09). Conclusions: Patients with NEC/MANEC have high malignant potential and poor outcomes. It is necessary to develop an effective approach and postoperative adjuvant treatment for patients with NEC/MANEC. |
Databáze: | OpenAIRE |
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