Ebola Virus Shed Glycoprotein Triggers Differentiation, Infection, and Death of Monocytes Through Toll-Like Receptor 4 Activation
| Autor: | Ndongala Michel Lubaki, Mathieu Iampietro, Alexander Bukreyev, Rodrigo I. Santos |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Programmed cell death THP-1 Cells viruses 030106 microbiology Supplement Articles Biology medicine.disease_cause Monocytes Pathogenesis 03 medical and health sciences Immune system Viral Envelope Proteins medicine Humans Immunology and Allergy Ebola Vaccines Receptor Glycoproteins chemistry.chemical_classification Toll-like receptor Ebola virus Cell Death Ebola vaccine virus diseases Cell Differentiation Hemorrhagic Fever Ebola Ebolavirus Virology Toll-Like Receptor 4 030104 developmental biology Infectious Diseases chemistry Host-Pathogen Interactions Glycoprotein |
| Zdroj: | The Journal of Infectious Diseases. 218:S327-S334 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiy406 |
| Popis: | A better understanding of the mechanisms used by Ebola virus to disable the host immune system and spread the infection are of great importance for development of new therapeutic strategies. We demonstrate that treatment of monocytic cells with Ebola virus shed glycoprotein (GP) promotes their differentiation resulting in increased infection and cell death. The effects were inhibited by blocking Toll-like receptor 4 pathway. In addition, high levels of shed GP were detected in supernatants of cells treated with Ebola vaccines. This study highlights the role of shed GP in Ebola pathogenesis and also in adverse effects associated with Ebola vaccines. |
| Databáze: | OpenAIRE |
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