Bladder pain syndrome treated with triple therapy with gabapentin, amitriptyline, and a nonsteroidal anti-inflammatory drug
| Autor: | Hee Jong Jeong, Dong Youp Han, Jea Whan Lee |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Drug
medicine.medical_specialty Gabapentin Visual analogue scale medicine.drug_class Bladder Pain Syndrome Urology media_common.quotation_subject lcsh:RC870-923 Anti-inflammatory chemistry.chemical_compound Interstitial cystitis medicine Nocturia Amitriptyline Visual analog scale Bladder Pain Adverse effect media_common Nonsteroidal business.industry medicine.disease lcsh:Diseases of the genitourinary system. Urology Neurology chemistry Anesthesia Original Article Neurology (clinical) medicine.symptom Bladder pain syndrome business medicine.drug |
| Zdroj: | International Neurourology Journal, Vol 14, Iss 4, Pp 256-260 (2010) International Neurourology Journal |
| ISSN: | 2093-6931 |
| Popis: | Purpose Bladder pain syndrome is a chronic disease that manifests as bladder pain, frequency, nocturia, and urgency. Gabapentin, amitriptyline, and nonsteroidal anti-inflammatory drugs are efficacious treatments for bladder pain syndrome. Here, we assessed the effect of triple therapy with these drugs in women with bladder pain syndrome. Methods Between May 2007 and May 2010, we conducted a prospective nonrandomized study on 74 patients with bladder pain syndrome. Of these patients, 38 (11 men and 27 women; mean age, 55.9 years; range, 25 to 77 years; mean follow-up, 12.6 months) were administered the interstitial cystitis (IC) symptom scales (O'Leary-Sant Symptom Index) and visual analog scale (VAS) 1, 3, and 6 months after treatment to assess the efficacy of triple therapy. Results The pretreatment O'Leary-Sant IC symptom score was 11.7, and the post-treatment scores were 4.4, 3.8, and 4.0 at 1, 3, and 6 months, respectively; the pretreatment problem index score was 10.5, and the post-treatment scores were 3.7, 2.7, and 2.9 at 1, 3, and 6 months, respectively. The pretreatment VAS score was 6.7, and the post-treatment scores were 1.8, 1.5, and 1.7 at 1, 3, and 6 months, respectively. The O'Leary-Sant IC symptom index and problem index and VAS scores improved considerably 1 month after treatment (P0.05). Conclusions Triple therapy was sufficiently effective in patients with bladder pain syndrome and caused no significant adverse effects. However, large-scale studies should be performed to verify our findings. |
| Databáze: | OpenAIRE |
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