Age-Related Alteration in Human Heart Collagen
| Autor: | C. R. Hamlin, Robert R. Kohn, R. J. Zwolinski |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Adolescent General Biochemistry Genetics and Molecular Biology Structure-Activity Relationship Internal medicine Age related medicine Humans Aged business.industry Myocardium Human heart Heart Middle Aged Myocardial function Tendon Hydroxyproline Microbial Collagenase medicine.anatomical_structure Endocrinology Collagenase Collagen Digestion business medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 152:362-365 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | SummaryA technique for the purification of insoluble human myocardial collagen is described. The digestion rate of old collagen with collagenase is much less than that of mature collagen. These findings are similar to those in human tendon collagen. It is suggested that progressive stabilization of collagen with age may be a generalized phenomenon, and responsible, in part, for the decline of myocardial function with age.The authors gratefully acknowledge the assistance of Dr. Lester Adelson and Dr. Charles S. Hirsch of the Cuyahoga County Coroner's Office for providing the heart tissue. |
| Databáze: | OpenAIRE |
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